About the Project

The operation systems (aka genomes) of all living organisms, named “The 4ⁿ-Genome Information Systems” (n = number of nucleotides) in this Assumptions Project, are complex, highly-organized, dynamic, and species- as well as individual-specific. During the last a few decades, a vast majority of research efforts for deciphering the biological logics, which control the normal and disease states of humans, animals, plants, and microbes, have focused on conventional genes. In humans and mice, conventional genes consist of approximately 2% of their respective 4ⁿ-genome information systems. Considering the decades-long enormous investments, the positive impacts of these research efforts on our tangible and accurate understanding of normal and disease biology are far less than expected.

As such, in the Assumptions Project, a range of assumptions, which serve as crucial foundations for biological studies, knowledge, and theories, are evaluated for whether they are sustainable with the perspectives of the quaternary and dynamic 4ⁿ-genome information systems. The outcomes of the evaluation are assembled into an essay in order to present to the public and to initiate discussions about the sustainability of the foundational assumptions of past, current, and future biological studies, knowledge, and theories.